dc.contributor.author |
Richardson, Simone I.
|
|
dc.contributor.author |
Kgagudi, Prudence
|
|
dc.contributor.author |
Manamela, Nelia P.
|
|
dc.contributor.author |
Kaldine, Haajira
|
|
dc.contributor.author |
Venter, Elizabeth M.
|
|
dc.contributor.author |
Pillay, Thanusha
|
|
dc.contributor.author |
Lambson, Bronwen E.
|
|
dc.contributor.author |
Van der Mescht, Mieke Adri
|
|
dc.contributor.author |
Hermanus, Tandile
|
|
dc.contributor.author |
Balla, Sashkia R.
|
|
dc.contributor.author |
De Beer, Zelda
|
|
dc.contributor.author |
De Villiers, Talita R.
|
|
dc.contributor.author |
Bodenstein, Annie
|
|
dc.contributor.author |
Van den Berg, Gretha
|
|
dc.contributor.author |
Du Pisanie, Marizane
|
|
dc.contributor.author |
Burgers, Wendy A.
|
|
dc.contributor.author |
Ntusi, Ntobeko A.B.
|
|
dc.contributor.author |
Abdullah, Fareed
|
|
dc.contributor.author |
Ueckermann, Veronica
|
|
dc.contributor.author |
Rossouw, Theresa
|
|
dc.contributor.author |
Boswell, Michael T.
|
|
dc.contributor.author |
Moore, Penny L.
|
|
dc.date.accessioned |
2024-04-18T13:24:07Z |
|
dc.date.available |
2024-04-18T13:24:07Z |
|
dc.date.issued |
2023-01 |
|
dc.description.abstract |
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA.4 and BA.5 variants caused
major waves of infections. Here, we assess the sensitivity of BA.4 to binding, neutralization, and antibodydependent
cellular cytotoxicity (ADCC) potential, measured by FcgRIIIa signaling, in convalescent donors
infected with four previous variants of SARS-CoV-2, as well as in post-vaccination breakthrough infections
(BTIs) caused by Delta or BA.1. We confirm that BA.4 shows high-level neutralization resistance regardless
of the infecting variant. However, BTIs retain activity against BA.4, albeit at reduced titers. BA.4 sensitivity to
ADCC is reduced compared with other variants but with smaller fold losses compared with neutralization and
similar patterns of cross-reactivity. Overall, the high neutralization resistance of BA.4, even to antibodies
from BA.1 infection, provides an immunological mechanism for the rapid spread of BA.4 immediately after
a BA.1-dominated wave. Furthermore, although ADCC potential against BA.4 is reduced, residual activity
may contribute to observed protection from severe disease. |
en_US |
dc.description.department |
Immunology |
en_US |
dc.description.department |
Internal Medicine |
en_US |
dc.description.librarian |
am2024 |
en_US |
dc.description.sdg |
SDG-03:Good heatlh and well-being |
en_US |
dc.description.sponsorship |
The South African Research Chairs Initiative of the Department of Science and Innovation and National Research Foundation of South Africa, the South African Medical Research Council SHIP program, the European Union-Africa Concerted Action on SAR-CoV-2 Virus Variant and Immunological Surveillance (CoVICIS) consortium, and the Centre for the AIDS Programme of Research in South Africa (CAPRISA), the Bill and Melinda Gates Foundation through the Global Immunology and Immune Sequencing for Epidemic Response (GIISER) program. |
en_US |
dc.description.uri |
https://www.cell.com/cell-reports-medicine/home |
en_US |
dc.identifier.citation |
Richardson, S.I., Kgagudi, P., Manamela, N.P. et al. 2023, 'Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera regardless of infecting variant', Cell Reports Medicine, vol. 4, art. 100910, pp. 1-10. https://DOI.org/10.1016/j.xcrm.2022.100910 |
en_US |
dc.identifier.issn |
2666-3791 |
|
dc.identifier.other |
10.1016/j.xcrm.2022.100910 |
|
dc.identifier.uri |
http://hdl.handle.net/2263/95663 |
|
dc.language.iso |
en |
en_US |
dc.publisher |
Cell Press |
en_US |
dc.rights |
© 2022 The Author(s).
This is an open access article under the CC BY license. |
en_US |
dc.subject |
Breakthrough infections |
en_US |
dc.subject |
Protection |
en_US |
dc.subject |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) |
en_US |
dc.subject |
Omicron BA.4 |
en_US |
dc.subject |
Omicron BA.5 |
en_US |
dc.subject |
Antibodydependent cellular cytotoxicity (ADCC) |
en_US |
dc.subject |
Binding |
en_US |
dc.subject |
Neutralization |
en_US |
dc.subject |
SDG-03: Good health and well-being |
en_US |
dc.title |
Antibody-dependent cellular cytotoxicity against SARS-CoV-2 Omicron sub-lineages is reduced in convalescent sera regardless of infecting variant |
en_US |
dc.type |
Article |
en_US |