• Investigation of non-prostatic in vitro prostate-specific membrane antigen expression in MCF-7 and MDA-MB-231 breast tumour cells 

  Tshabalala, Malvin Thabani (University of Pretoria, 2020)

  Introduction Breast and prostate cancer mutually represent the most commonly occurring malignancies worldwide in women and men, respectively. The mutative state, recurrence capacity, resistance to conventional chemotherapy, ...
• Prevalence of SLCO1B1 single nucleotide variations, and their association with statin intolerance in hypercholesterolaemic patients in Gauteng, South Africa 

  De Beer, René (University of Pretoria, 2020)

  Statins, the standard treatment for hypercholesterolaemia, have been associated with side effects, including statin intolerance. This study determined the prevalence of SLCO1B1 single nucleotide variations (SNVs) and ...
• Erythropoietin treatment in anaemic patients at the Nephrology Unit of the Steve Biko Academic Hospital - a retrospective, cross-sectional study 

  Kok, Elandre (University of Pretoria, 2020)

  Anaemia in chronic kidney disease (CKD) mostly results from a decrease in the production of erythropoietin (EPO) by the failing kidney. CKD progression requires treatment with erythropoiesis-stimulating agents and iron ...
• Assessing modified chitosan wound dressings to enhance wound healing in the porcine model 

  Khathide, Bongai (University of Pretoria, 2020-08)

  Dressings enhancing wound healing can improve the outcome of wounds where tissue replacement is required, like for burns and ulcers. Treatment of these wounds is complex due to their depth and excessive tissue loss. ...
• Assessing cardiotonic steroids involvement in hypertensive rat models with Helicobacter pylori infections 

  Masso, Zelie Flavienne (University of Pretoria, 2020-07-31)

  Introduction: Hypertension is an important public health challenge worldwide, being the leading cause of cardiovascular disease, morbidity and mortality. It is particularly prevalent in people in sub-Saharan Africa, ...
• Prescription patterns and drug duplication in specialist outpatient clinics at a tertiary hospital in the greater Tshwane metropolitan area 

  Ncube, Musawenkosi Genius (University of Pretoria, 2020)

  Background: Tertiary hospitals have multiple specialist outpatient clinics attended by patients suffering from various comorbid diseases. This results in individuals attending more than one clinic per month, since dedicated ...
• Assessing inter-method agreement of drug-based phenotyping metrics between dried blood spot and plasma sampling 

  Leuschner, Machel (University of Pretoria, 2019)

  Introduction: Pharmacokinetic variability in response to pharmacotherapy contribute to adverse drug reactions, drug-drug interaction and therapeutic failure seen in clinical practice. Poor therapeutic response to medication ...
• Identification of single nucleotide polymorphisms in inflammatory bowel disease patients on azathioprine therapy 

  Adam, Lyla (University of Pretoria, 2019)

  Azathioprine, an immunosuppressant used for many years in the medical sector to maintain long term disease remission in inflammatory bowel disease has a side effect profile that has raised many concerns over the years with ...
• Comparison of metabalome attenuation in monolayer and three dimensional hepatocyte cultures 

  De Koker, Gerben (University of Pretoria, 2019)

  Introduction: Drugs have been removed from the market for years due to toxicity screening. The highest attrition from the market can be seen by drugs that cause hepatotoxicity. Most drugs are metabolised by phase I cytochrome ...
• Identification of mycolic acid class ratios from Mycobacterium species using liquid chromatography-mass spectrometry 

  Naicker, Brendon (University of Pretoria, 2019)

  Alongside the recent technology advancements in liquid chromatography (LC) and mass spectrometry (MS) instrumentation there has also been steady progress made with respect to the systematic lipidomic studies of Mycobacterium ...
• Mass spectrometric proteomic profiling of acute wound healing processes in the porcine model 

  Sheva, Kim Lisa (University of Pretoria, 2019)

  Wounds are a common occurrence and generally heal well within a short time depending on whether tissue needs to be replaced or not. Although there is an understanding of the physiological processes taking place during wound ...
• Spatial characterization of the BT-20 triple negative breast cancer spheroidal model 

  Ncube, Keith Ntokozo (University of Pretoria, 2019)

  Breast cancer is a commonly diagnosed cancer in women, with increasing diagnosis and mortality rates. The triple-negative sub-type of the disease is characterised by lack of hormone-receptor overexpression, exhibition of ...
• The combined effects or arsenic cadmium and mercury on hepatocarcinoma and neuroblastoma cells in vitro 

  Yousaf, Muhammad (University of Pretoria, 2018)

  Among several heavy metallic elements, arsenic, cadmium and mercury are most toxic in the environment. These metals are acquired by humans through food and water, which result in severe health related issues. One of the ...
• The effect of three Ghanaian plants on fibroblast migration, inflammation and bacterial growth in vitro 

  Yahaya, Ewura Seidu (University of Pretoria, 2018)

  Medical conditions which cause morbidity and mortality, such as chronic wounds and infection, lead to significant medical costs. Much of the world's population is dependent on alternative medicine, of which herbal medicine ...
• Comparative analysis of a two-dimensional and three-dimensional model of BT-20 triple negative breast carcinoma cells in response to an antiproliferative agent 

  Wang, Jie (University of Pretoria, 2018)

  Triple-negative breast cancer (TNBC) lacks the expression of estrogen receptor-alpha, progesterone receptor and human epidermal growth factor receptor 2 (HER2). The lack of dependence on estrogen by TNBC cells makes ...
• The prevalence of eight single nucleotide variations in overweight and obese participants 

  Sansom, Bianca (University of Pretoria, 2018)

  Introduction Obesity is a growing epidemic not just nationally but worldwide and is responsible for a substantial economic burden in both developed and developing countries. Obesity is a major risk factor for type 2 ...
• How traditional healers diagnose and treat diabetes mellitus in the Pretoria Mamelodi area and how do these purported medications comply with complementary and alternative medicine regulations 

  Ondo, Zaina Gabrielle (University of Pretoria, 2019)

  Introduction Medicine regulation and control is not an option but a necessity for national health programmes. In South Africa, a new amended regulation required a review of complementary and alternative medicine (CAMs) ...
• Proportional determination and reasons for medication returns at a tertiary academic hospital in Gauteng 

  Maluleke, Enos Eric (University of Pretoria, 2018)

  South Africa has a quadruple burden or disease which leads to increased pharmaceutical expenditure on communicable and non-communicable diseases. This study aimed to determine the proportion of patients that return unused ...
• A simultaneous quantitative determination of both natural and synthetic cannabinoids in bio-matrix by ultra-high pressure liquid chromatography tandem mass spectrometry 

  Schillack, Heiko (University of Pretoria, 2018)

  Numerous publications outlining the quantitative determination and semi-quantitative screening for both parent and metabolites of the natural plant derived cannabinoids have been reviewed due to the widespread use and abuse ...
• A comparative proteomic and glycoproteomic study of platelets from patients with diabetes and non-diabetic healthy individuals 

  Mlambo, Shamiso Shelter (University of Pretoria, 2018)

  Introduction: Diabetes mellitus is considered one of the four major non-communicable disease with the global prevalence of this disease nearly doubling over the past 40 years, making it one of the leading causes of morbidity ...

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