Pharmacology: Recent submissions

Now showing items 1-20 of 335

Highlights of basic and clinical pharmacology from Africa

Steenkamp, Vanessa (Wiley, 2023-04)

The special themed issue; ‘Highlights of Basic and Clinical Pharmacology from Africa’ is a compilation of contributions from both basic and clinical research from the African continent. The publications included in this ...
Critical assessment of phenotyping cocktails for clinical use in an African context

Leuschner, Machel; Cromarty, Allan Duncan (MDPI, 2023-07-05)

Interethnic and interindividual variability in in vivo cytochrome P450 (CYP450)-dependent metabolism and altered drug absorption via expressed transport channels such as P-glycoprotein (P-gp) contribute to the adverse ...
A simplified workflow with end-point validation of real-time electrical cell-substrate impedance sensing of retinoic acid stimulated neurogenesis in human SH-SY5Y cells in vitro

Joos‑Vandewalle, Julia; Steenkamp, Vanessa; Prinsloo, Earl (BMC, 2023-06-01)

OBJECTIVE : Retinoic acid (RA) is known to transition proliferating SH-SY5Y neuroblastoma cells towards functional neurons. However, the activity of RA is restricted due to its photolability where any findings from prolonged ...
Comparative evaluation of the cytotoxicity of doxorubicin in BT-20 triple-negative breast carcinoma monolayer and spheroid cultures

Ncube, Keith Ntokozo; Jurgens, Tamarin; Steenkamp, Vanessa; Cromarty, Allan Duncan; Van den Bout, Jan Iman (MDPI, 2023-05-19)

Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical drug testing platforms, as they circumvent limitations associated with traditional monolayer cell cultures. However, many of these ...
One-step synthesis of metal oxide nanoparticles using cannabidiol: characterisation and cytotoxicity assessment in human keratinocyte cells

Josiah, Andrea Jess; Pillai, Sreejarani K.; Cordier, Werner; Nell, Margo Judith; Lall, Namrita; Twilley, Danielle; Ray, Suprakas Sinha (Wiley, 2024-02)

Please read abstract in the article.
A narrative review of antibiotic prescribing practices in primary care settings in South Africa and potential ways forward to reduce antimicrobial resistance

Chigome, Audrey; Ramdas, Nishana; Skosana, Phumzile; Cook, Aislinn; Schellack, Natalie; Campbell, Stephen; Lorenzetti, Giulia; Saleem, Zikria; Godman, Brian; Meyer, Johanna C. (MDPI, 2023-10-14)

There are concerns with the current prescribing of antibiotics in both the private and public primary care settings in South Africa. These concerns need to be addressed going forward to reduce rising antimicrobial ...
South African physiotherapists’ attitudes to medicine prescription as an extension of practice

Kakono, Tsungirirai V.; Mathye, Desmond; Brand, S.J. (Sarel); Cordier, Werner (AOSIS Open Journals, 2023-06-23)

BACKGROUND : The extension of medicine prescription rights to other healthcare providers was proposed to reduce pharmacotherapeutic service delivery challenges in the South African healthcare sector. The scope of practice ...
Exploring the ex vivo effects of Naja mossambica venom on the ultrastructure and viscoelastic properties of human blood

Chamboko, Tanyaradzwa Dellah; Love, Jenna; Strydom, Morne; Bester, Janette (Elsevier, 2024-01)

BACKGROUND : Venomous snake bites have been listed as a neglected tropical disease by the World Health Organization. The Mozambique spitting cobra (Naja mossambica) is found in Sub-Saharan African countries, and its venom ...
Treatment of the common cold with herbs used in Ayurveda and Jamu : monograph review and the science of ginger, liquorice, turmeric and peppermint

Wardani, Retno S.; Schellack, Natalie; Govender, Tamlyn; Dhulap, Abhay N.; Utami, Prapti; Malve, Vinod; Wong, Yong Chiat (Bioexcel Publishing, 2023-06)

BACKGROUND : The common cold is typically managed with decongestants, antihistamines, antitussives and antipyretics. In addition to these established medications, herbal ingredients have been used over centuries to help ...
Hybrid compounds containing carvacrol scaffold : in vitro antibacterial and cytotoxicity evaluation

Mbese, Zintle; Nell, Margo Judith; Fonkui, Youmbi Thierry; Ndinteh, Derek Tantoh; Steenkamp, Vanessa; Aderibigbe, Blessing Atim (Bentham Science Publishers, 2022-03)

Please read abstract in the article.
Knowledge, attitude and practices of self-medication including antibiotics among health care professionals during the COVID-19 pandemic in Pakistan : findings and implications

Mustafa, Zia Ul; Iqbal, Shahid; Asif, Hafiz Rahil; Salman, Muhammad; Jabbar, Sehar; Mallhi, Tauqeer Hussain; Khan, Yusra Habib; Sono, Tiyani Milta; Schellack, Natalie; Meyer, Johanna C.; Godman, Brian (MDPI, 2023-02)

Since the emergence of COVID-19, several different medicines including antimicrobials have been administered to patients to treat COVID-19. This is despite limited evidence of the effectiveness of many of these, fueled by ...
Assessing the clinical characteristics and management of COVID-19 among pediatric patients in Ghana : findings and implications

Sefah, Israel; Sarkodie, Seth Adade; Pichierri, Giuseppe; Schellack, Natalie; Godman, Brian (MDPI, 2023-02)

There is an increasing focus across countries on researching the management of children admitted to hospital with COVID-19. This stems from an increasing prevalence due to new variants, combined with concerns with the ...
Stability, morphology, and effects of in vitro digestion on the antioxidant properties of polyphenol inclusion complexes with -cyclodextrin

Ntuli, Sunday; Leuschner, Machel; Bester, Megan; Serem, June Cheptoo (MDPI, 2022-06-14)

Polyphenols are inversely associated with the incidence of chronic diseases, but therapeutic use is limited by poor stability and bioaccessibility. Encapsulation has been shown to overcome some of these limitations. A ...
Zebrafish behavioral response to ivermectin : insights into potential neurological risk

Powrie, Yigael; Strydom, Morne A.; Aucamp, Marique; Schellack, Natalie; Steenkamp, Vanessa; Smith, Carine (Elsevier, 2022-12)

Ivermectin is a well‐known and widely used anti‐parasitic drug. Recently, in vitro data suggest anti‐viral efficacy of the drug, albeit at much higher concentrations than currently approved. Despite warnings by ...
A national, multicentre web-based point prevalence survey of antimicrobial use in community healthcare centres across South Africa and the implications

Skosana, Phumzile; Schellack, Natalie; Godman, Brian; Kurdi, Amanj; Bennie, Marion; Kruger, Danie; Meyer, Johanna C. (Taylor and Francis, 2022)

OBJECTIVE : Up to 90% of antimicrobials globally are prescribed and dispensed in ambulatory care. However, there are considerable gaps regarding the extent and rationale for their use especially in low- and middle-income ...
Web-based point prevalence survey of antimicrobial use and quality indicators at Raleigh Fitkin Memorial Hospital in Eswatini and the implications

Gwebu, Prudence; Meyer, Johanna C.; Schellack, Natalie; Matsebula-Myeni, Zinhle; Godman, Brian (Routledge, 2022)

Currently there is limited knowledge regarding antimicrobial utilization patterns among public hospitals in Eswatini. This is a concern given rising resistance rates among African countries. This study aimed to address ...
Targeting specific checkpoints in the management of SARS-CoV-2 induced cytokine storm

Abubakar, Abdullahi Rabiu; Ahmad, Rahnuma; Rowaiye, Adekunle Babajide; Rahman, Sayeeda; Iskandar, Katia; Dutta, Siddhartha; Oli, Angus Nnamdi; Dhingra, Sameer; Tor, Maryam Abba; Etando, Ayukafangha; Kumar, Santosh; Irfan, Mohammed; Gowere, Marshall; Chowdhury, Kona; Jahan, Dilshad; Schellack, Natalie; Haque, Mainul (MDPI, 2022-03-25)

COVID-19-infected patients require an intact immune system to suppress viral replication and prevent complications. However, the complications of SARS-CoV-2 infection that led to death were linked to the overproduction ...
Social media and COVID-19-perceptions and public deceptions of ivermectin, colchicine and hydroxychloroquine : lessons for future pandemics

Schellack, Natalie; Strydom, Morne A.; Pepper, Michael Sean; Herd, Candice Lee; Hendricks, Candice Laverne; Bronkhorst, Elmien; Meyer, Johanna C.; Padayachee, Neelaveni; Bangalee, Varsha; Truter, Ilse; Ellero, Andrea Antonio; Myaka, Thulisa; Naidoo, Elysha; Godman, Brian (MDPI, 2022-04)

The capacity for social media to influence the utilization of re-purposed medicines to manage COVID-19, despite limited availability of safety and efficacy data, is a cause for concern within health care systems. This ...
Mechanisms facilitating the uptake of carboxyl-polythene glycol-functionalized gold nanoparticles into multicellular spheroids

Fobian, Seth-Frerich; Petzer, Melissa; Vetten, Melissa; Steenkamp, Vanessa; Gulumian, Mary; Cordier, Werner (Oxford University Press, 2022-09)

OBJECTIVES : Nanomedicines represent theragnostic alternatives to traditional candidate drugs, with increased targeting and delivery potential due to their size and functional tailorability. Biological activity typically ...
Augmented reality technology : a systematic review on gaming strategy for medication adherence

Adetunji, R.O.; Strydom, Morne A.; Herselman, M.E.; Botha, A. (Springer, 2022-10)

As global health concerns become more complex, technological intervention is needed to achieve the Sustainable Development Goal. This study explores the use of the internet of things (IoT) and augmented reality (AR) ...

Now showing items 1-20 of 335

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