• Changes in prevalence and seasonality of pathogens identified in acute respiratory tract infections in hospitalised individuals in rural and urban settings in South Africa; 2018–2022 

  Davids, Michaela; Johnstone, Siobhan; Mendes, Adriano; Brecht, Gadean; Avenant, Theunis Johannes; Du Plessis, Nicolette Marie; De Villiers, Maryke; Page, N.A. (Nicola); Venter, Marietjie (MDPI, 2024-03)

  Severe acute respiratory tract infections (SARIs) has been well described in South Africa with seasonal patterns described for influenza and respiratory syncytial virus (RSV), while others occur year-round (rhinovirus and ...
• Healthcare delivery 

  Schneider, H.; Kredo, T.; Odendaal, W.A.; Abdullah, Fareed (South African Medical Association, 2023-02)

  We report here on the process and findings of a research prioritisation exercise for universal health coverage (UHC) in South Africa, conducted during the course of 2019. As plans to roll out National Health Insurance ...
• Profile of human papillomavirus genotypes in breast and oesophageal cancer patients in Pretoria, South Africa 

  Maroga, N.; Mokoena, Taole; Musekiwa, Alfred; Bida, Meshack; Kgomo, Mpho K.; Lebelo, R. (South African Medical Association, 2023-07)

  BACKGROUND : The association between human papillomavirus (HPV) and cervical cancer is well established, and cervical cancer can be prevented through HPV vaccination. Little has been reported on the association between HPV ...
• What are health policy and systems research priorities for universal health coverage in South Africa? 

  Schneider, H.; Kredo, T.; Odendaal, W.A.; Abdullah, Fareed (South African Medical Association, 2023-02)

  We report here on the process and findings of a research prioritisation exercise for universal health coverage (UHC) in South Africa, conducted during the course of 2019. As plans to roll out National Health Insurance ...
• COVID-19 severity and in-hospital mortality in an area with high HIV prevalence 

  Boswell, Michael; Maimela, T.C.R. (Tshegofatso); Hameiri-Bowen, Dan; Riley, George; Malan, Albertus; Steyn, Nickietta; Nolutshungu, Nomonde; De Villiers, Talita R.; De Beer, Zelda; Mathabathe, John; Tshabalala, Khanyisile; Abdullah, Fareed; Ramlall, Rajiev; Heystek, Marthinus J.; Basu, Debashis; Rheeder, Paul; Ueckermann, Veronica; Van Hougenhouck-Tulleken, W.G. (Wesley) (AOSIS, 2023-01-27)

  BACKGROUND : HIV infection causes immune dysregulation affecting T-cell and monocyte function, which may alter coronavirus disease 2019 (COVID-19) pathophysiology. OBJECTIVES : We investigated the associations among ...
• Late-onset efavirenz toxicity : a descriptive study from Pretoria, South Africa 

  Munsami, Lyneshree; Schutte, Clara-Maria; De Villiers, Maryke; Hiesgen, Juliane (AOSIS, 2023-01-19)

  BACKGROUND : The neuropsychiatric side effects of efavirenz occur mainly early during treatment and are usually mild. A lesser-known and serious complication is late-onset efavirenz toxicity causing ataxia and encephalopathy. ...
• Factors associated with COVID-19 vaccine uptake among schoolgoing adolescent girls and young women in South Africa 

  Bergh, Kate; Jonas, Kim; Duby, Zoe; Govindasamy, Darshini; Mathews, Catherine; Reddy, Tarylee; Slingers, Nevilene; Whittle, Granville; Abdullah, Fareed (MDPI, 2023-10-11)

  BACKGROUND : By October 2022, vaccination rates with at least one dose of a COVID-19 vaccine were low among adolescent girls aged 12–17 (38%) and young women aged 18–34 (45%) in South Africa. This study aimed to measure ...
• Cavernous transformation of the portal vein a rare phenomenon 

  Bosenberg, L.H.; Thomas, P. (In House Publications, 2022)

  Cavernous transformation of the portal vein is a complication of a prior portal vein thrombosis and carries a very poor prognosis. It is associated with portal hypertension, and the massive ascites that develops as a ...
• Pro-inflammatory interactions of dolutegravir with human neutrophils in an in vitro study 

  Theron, Annette J.; Anderson, Ronald; Madzime, Morris; Rossouw, Theresa M.; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Cholo, Moloko C.; Kwofie, Luyanda Laura Illicia; Feldman, Charles; Tintinger, Gregory (MDPI, 2022-12-19)

  There is increasing awareness of an association between the uptake of the HIV integrase inhibitor, dolutegravir, in first-line antiretroviral regimens with unusual weight gain and development of the metabolic syndrome, ...
• Cryptogenic, embolic stroke-looking backstage 

  Ker, James A. (Elsevier, 2022-05)

  Stroke is a common and devastating event and the majority of cases are caused by thromboembolism from the left atrium, left ventricle or left sided valves. This case report describes a case of embolic stroke with the origin ...
• Adjustment of insulin pump settings in Type 1 diabetes management : Advisor Pro device compared to physicians’ recommendations 

  Nimri, Revital; Oron, Tal; Muller, Ido; Kraljevic, Ivana; Alonso, Montserrat Martin; Keskinen, Paivi; Milicic, Tanja; Oren, Asaf; Christoforidis, Athanasios; Den Brinker, Marieke; Bozzetto, Lutgarda; Bolla, Andrea Mario; Krcma, Michal; Rabini, Rosa Anna; Tabba, Shadi; Smith, Lizl; Vazeou, Andriani; Maltoni, Giulio; Giani, Elisa; Atlas, Eran; Phillip, Moshe (Sage, 2022-03)

  AIMS : To compare insulin dose adjustments made by physicians to those made by an artificial intelligence-based decision support system, the Advisor Pro, in people with type 1 diabetes (T1D) using an insulin pump and ...
• Decreased severity of disease during the first global Omicron variant COVID-19 outbreak in a large hospital in Tshwane, South Africa 

  Abdullah, Fareed; Myers, J.; Basu, Debashis; Tintinger, Gregory; Ueckermann, Veronica; Mathebula, M.; Ramlall, R.; Spoor, S.; De Villiers, T.; Van der Walt, Z.; Cloete, Jeane; Soma-Pillay, Priya; Rheeder, Paul; Paruk, Fathima; Engelbrecht, Adel; Lalloo, Vidya; Myburg, M.; Kistan, J.; Van Hougenhouck-Tulleken, W.G. (Wesley); Boswell, Michael T.; Gray, G.; Welch, R.; Blumberg, Lucille Hellen; Jassat, W. (Elsevier, 2022-03)

  INTRODUCTION : The coronavirus disease 2019 (COVID-19) first reported in Wuhan, China in December 2019 is a global pandemic that is threatening the health and wellbeing of people worldwide. To date there have been more ...
• SARS-CoV-2 Beta and Delta variants trigger Fc effector function with increased cross-reactivity 

  Richardson, Simone I.; Manamela, Nelia P.; Motsoeneng, Boitumelo M.; Kaldine, Haajira; Ayres, Frances; Makhado, Zanele; Mennen, Mathilda; Skelem, Sango; Williams, Noleen; Sullivan, Nancy J.; Misasi, John; Gray, Glenda G.; Bekker, Linda‑Gail; Ueckermann, Veronica; Rossouw, Theresa M.; Boswell, M.T.; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Moore, Penny L. (Cell Press, 2022-02-15)

  Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VOCs) exhibit escape from neutralizing antibodies, causing concern about vaccine effectiveness. However, while non-neutralizing cytotoxic ...
• Ad26.COV2.S breakthrough infections induce high titers of neutralizing antibodies against Omicron and other SARS-CoV-2 variants of concern 

  Kitchin, Dale; Richardson, Simone I.; Van der Mescht, Mieke Adri; Motlou, Thopisang; Mzindle, Nonkululeko; Moyo-Gwete, Thandeka; Makhado, Zanele; Ayres, Frances; Manamela, Nelia P.; Spencer, Holly; Lambson, Bronwen; Oosthuysen, Brent; Kaldine, Haajira; Du Pisanie, Marizane; Mennen, Mathilda; Skelem, Sango; Williams, Noleen; Ntusi, Ntobeko A.B.; Burgers, Wendy A.; Gray, Glenda G.; Bekker, Linda-Gail; Boswell, Michael T.; Rossouw, Theresa M.; Ueckermann, Veronica; Moore, Penny L. (Cell Press, 2022-03-15)

  The Janssen (Johnson & Johnson) Ad26.COV2.S non-replicating viral vector vaccine has been widely deployed for COVID-19 vaccination programs in resource-limited settings. Here we confirm that neutralizing and binding ...
• A risk measurement tool for targeted HIV prevention measures amongst young pregnant and lactating women in South Africa 

  Ramraj, Trisha; Abdelatif, Nada; Chirinda, Witness; Abdullah, Fareed; Kindra, Gurpreet; Goga, Ameena Ebrahim (BMC, 2022-06-30)

  BACKGROUND : We aimed to develop and validate a tool to identify which pregnant/lactating young South African women (≤ 24 years) are at risk of HIV infection. METHODS : Data from three national South African Prevention ...
• Decline in antibody responses to SARS-CoV-2 post-vaccination poses a risk to health care workers 

  Worsley, Catherine M.; Van der Mescht, Mieke Adri; Hoffmann, Daniel; Meyer, Pieter Willem Adriaan; Ueckermann, Veronica; Rossouw, Theresa M. (Elsevier, 2022-09)

  No abstract available.
• Dolutegravir potentiates platelet activation by a calcium-dependent, ionophore-like mechanism 

  Madzime, Morris; Theron, Annette J.; Anderson, Ronald; Tintinger, Gregory; Steel, Helen C.; Meyer, Pieter Willem Adriaan; Nel, Jan Gert; Feldman, Charles; Rossouw, Theresa M. (Taylor and Francis, 2022)

  Please read abstract in the article.
• Neuro-Behcet – clinical and radiological findings in a patient of sub-Saharan African origin 

  Pretorius, Johannes Jacobus; Hiesgen, Juliane; Myburgh, Michael; Suleman, Farhana Ebrahim (Elsevier, 2022-03)

  Behçet’s disease is a rare, systemic variable vessel vasculitis mostly seen in patients from the Middle East, Northern Africa and Central Asia. Neuro-Behçet disease (NBD) is often diagnosed in patients with known Behçet’s ...
• Effectiveness of an adapted diabetes nutrition education program on clinical status, dietary behaviors and behavior mediators in adults with type 2 diabetes : a randomized controlled trial 

  Muchiri, Jane Wanjiku; Gericke, Gerda J.; Rheeder, Paul (Springer, 2021-06)

  PURPOSE : This study evaluated the effectiveness of an adapted social-cognitive theory underpinned diabetes nutrition education program (NEP) on: clinical (HbA1c, BMI, blood lipids, blood pressure) and selected dietary ...
• Cross-reactive neutralizing antibody responses elicited by SARS-CoV-2 501Y.V2 (B.1.351) 

  Moyo‑Gwete, Thandeka; Madzivhandila, Mashudu; Makhado, Zanele; Ayres, Frances; Mhlanga, Donald; Oosthuysen, Brent; Lambson, Bronwen E.; Kgagudi, Prudence; Tegally, Houriiyah; Iranzadeh, Arash; Doolabh, Deelan; Tyers, Lynn; Chinhoyi, Lionel R.; Mennen, Mathilda; Skelem, Sango; Marais, Gert; Wibmer, Constantinos K.; Bhiman, Jinal N.; Ueckermann, Veronica; Rossouw, Theresa M.; Boswell, Michael T.; De Oliveira, Tulio (Massachusetts Medical Society, 2021-06)

  No abstract available.

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