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Chemical Pathology: Recent submissions
Now showing items 1-20 of 86
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(AOSIS, 2023-12-12)BACKGROUND : Accurate potassium measurements are necessary for effective clinical management of hyperkalaemia. Pre-analytical factors may affect laboratory measurements, leading to erroneous results and inappropriate ...
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(MDPI, 2023-03)Preclinical studies show that the anticancer actions of vitamin D metabolites are mediated by apoptosis, inhibition of cell proliferation and induction of cell cycle arrest. Cervical cancer cells express an autocrine vitamin ...
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(International Federation of Clinical Chemistry and Laboratory Medicine, 2022-08)The Coronavirus Disease 2019 (COVID-19) pandemic is caused by the SARS-CoV-2 RNA virus. Nucleic acid amplification testing (NAAT) is the mainstay to confirm infection. A large number of reverse transcriptase polymerase ...
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(Clinics Cardive Publishing, 2022-09)Sudden unexpected infant death (SUDI) is reported to be an extraordinarily high burden in sub-Saharan Africa, with the incidence rate in South Africa among the highest in the world. It is common for the cause of many ...
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(AOSIS, 2023-04-14)INTRODUCTION : Liddle syndrome is an autosomal dominantly inherited disorder usually arising from single mutations of the genes that encode for the alpha, beta and gamma epithelial sodium channel (ENaC) subunits. This leads ...
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(University of Pretoria, 2023)Cervical cancer is the leading cause of cancer-related mortalities in South African women. Vitamin D and its metabolites exert anti-cancer actions in various cancers; however, few studies have explored the effects of vitamin ...
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(BMJ Publishing Group, 2023-09)Ketamine, a dissociative anaesthetic drug, acts on the central nervous system (CNS) primarily through antagonism of the n-methyl-d-aspartate (NMDA) receptor. Methods of administration include intravenous, intramuscular, ...
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(AOSIS, 2022-06-23)BACKGROUND : Formalin-fixed paraffin-embedded (FFPE) tissue archives in hospitals, biobanks, and others offer a vast collection of extensive, readily available specimens for molecular testing. Unfortunately, the use of ...
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Postmortem genetic testing in young individuals : what clinical medical practitioners need to know (Health and Medical Publishing Group, 2022-12)The death of a young person is most often a tragic occurrence, more so when this death was unexpected. Forensic pathologists are mandated to investigate such deaths, and there has been a strong move internationally towards ...
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(Health and Medical Publishing Group, 2022-12)Cardiovascular diseases (CVDs) are ever-increasing, and as such are considered to be one of the most concerning public health burdens worldwide. They remain the leading cause of death across the world (~17.7 million deaths ...
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(Elsevier, 2022-09)No abstract available.
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(AOSIS, 2021-10)Serological tests based on the enzyme immunoassay (EIA) are the primary tool for the diagnosis of human immunodeficiency virus (HIV) in adults and have rapidly evolved to quicker, affordable and more accurate test formats ...
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Flow cytometric analysis of apoptotic biomarkers in actinomycin D-treated SiHa cervical cancer cells (MyJove Corporation, 2021-08-26)Apoptosis biomarkers were investigated in actinomycin D-treated SiHa cervical cancer cells using a benchtop flow cytometer. Early biomarkers (Annexin V and mitochondrial membrane potential) and late biomarkers (caspases ...
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(Frontiers Research Foundation, 2021-09-03)Anti-Müllerian Hormone (AMH) is a 140 kDa homodimeric glycoprotein consisting of two identical subunits linked by disulphide bonds and is synthesised by the testes and ovaries. Its clinical applications are prediction ...
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(Springer, 2020-12)Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB) and considered as serious public health concern worldwide which kills approximately five thousand people every day. Therefore, TB drug ...
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(Korean Society for Laboratory Medicine, 2021)Antibodies have proven to be central in the development of diagnostic methods over decades, moving from polyclonal antibodies to the milestone development of monoclonal antibodies. Although monoclonal antibodies play a ...
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(MDPI, 2020-02)Vitamin D has displayed anti-cancer actions in numerous in vitro studies. Here, we investigated the anti-cancer actions of cholecalciferol, a vitamin D precursor, on a metastatic cervical cancer cell line, namely, CaSki. ...
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(BMJ Publishing Group Group, 2021-06)Hypercalcaemia is seldom encountered in paediatric patients, and calcium levels are not routinely included in investigations. Associated symptoms such as nausea, vomiting, dehydration and abdominal pain are non-specific, ...
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(MDPI, 2020-12)Vitamin D is a steroid hormone crucial for bone mineral metabolism. In addition, vitamin D has pleiotropic actions in the body, including anti-cancer actions. These anti-cancer properties observed within in vitro studies ...
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(Elsevier, 2021-03)Nipah virus (NiV) infections are highly contagious and can cause severe febrile encephalitis. An outbreak of NiV infection has reported high mortality rates in Southeast Asian countries including Bangladesh, East Timor, ...
Now showing items 1-20 of 86