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Browsing Surgery by Subject "Drug discovery"

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Synergistic in-vitro effects of combining an antiglycolytic, 3-bromopyruvate, and a bromodomain-4 inhibitor on U937 myeloid leukemia cells

Kapp, Nicolette; Stander, Xiao Xing; Stander, Barend Andre (Lippincott, Williams & Wilkins, 2018-06)

This project investigated the in-vitro effects of a glycolytic inhibitor, 3-bromopyruvate (3-BrP), in combination with and a new in silico-designed inhibitor of the bromodomain-4 (BRD-4) protein, ITH-47, on the U937 acute ...

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