• Effect of 2-methoxyestradiol treatment on early- and late-stage breast cancer progression in a mouse model 

  Peta, Kimberly; Durandt, Chrisna; Van Heerden, M.B. (Marlene); Joubert, Anna Margaretha; Pepper, Michael Sean; Ambele, Melvin Anyasi (Wiley, 2023-10)

  The prevalence of breast cancer (BC) continues to increase and is the leading cause of cancer deaths in many countries. Numerous in vitro and in vivo studies have demonstrated that 2‐methoxyestradiol (2‐ME) has ...
• An in vitro investigation of l-kynurenine, quinolinic acid, and kynurenic acid on B16 F10 melanoma cell cytotoxicity and morphology 

  Basson, Charlize; Serem, June Cheptoo; Hlophe, Yvette Nkondo; Bipath, Priyesh (Wiley, 2023-10)

  The metastatic behavior of melanoma has accentuated the need for specific therapy targets. Compounds, namely L‐kynurenine (L‐kyn), quinolinic acid (Quin), and kynurenic acid (KA) previously displayed antiproliferative ...
• How nuclear envelope dynamics can direct laminopathy phenotypes 

  Van Heerden, David; Klima, Stefanie; Van den Bout, Iman (Elsevier, 2024-02)

  The nuclear envelope separates the genome from the cytoplasmic environment. However, the nuclear envelope is also physically associated with the genome and exerts influence on gene expression and genome modification. The ...
• Scanning electron and atomic force microscopic analysis of erythrocytes in a cohort of atopic asthma patients - a pilot study 

  Alummoottil, Sajee; Van Rooy, Mia-Jeanne; Bester, Janette; Grobbelaar, C.W. (Craig); Phulukdaree, Alisa (MDPI, 2023-03)

  BACKGROUND : Non-communicable diseases are often associated with chronic inflammation, placing patients suffering from these conditions at a higher risk of thrombosis and other complications. The pathophysiology of asthma ...
• Males, older age, increased training, chronic diseases, allergies, and history of injury are independent risk factors associated with a history of exercise-associated muscle cramping in distance runners in 76 654 race entrants - SAFER XXIX 

  De Jager, Izaan; Schwellnus, Martin Peter; Sewry, Nicola; Viljoen, Carel T.; Korkie, Elzette; Swanevelder, Sonja; Jordaan, Esme (Lippincott Williams and Wilkins, 2023-09)

  OBJECTIVE : To determine independent risk factors associated with a history of exercise-associated muscle cramps (hEAMCs) in distance runner race entrants in a community-based mass participation event. DESIGN : ...
• Comparative evaluation of the cytotoxicity of doxorubicin in BT-20 triple-negative breast carcinoma monolayer and spheroid cultures 

  Ncube, Keith Ntokozo; Jurgens, Tamarin; Steenkamp, Vanessa; Cromarty, Allan Duncan; Van den Bout, Jan Iman (MDPI, 2023-05-19)

  Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical drug testing platforms, as they circumvent limitations associated with traditional monolayer cell cultures. However, many of these ...
• Decoding the synergistic potential of MAZ-51 and zingerone as therapy for melanoma treatment in alignment with sustainable development goals 

  Letsoalo, Kganya; Nortje, Evangeline; Patrick, Sean Mark; Nyakudya, Trevor Tapiwa; Hlophe, Yvette Nkondo (Wiley, 2024-03)

  Melanoma, an invasive class of skin cancer, originates from mutations in melanocytes, the pigment-producing cells. Globally, approximately 132,000 new cases are reported each year, and in South Africa, the incidence stands ...
• Long-term maintenance of clinical responses by individual patients with polyarticular-course juvenile idiopathic arthritis treated with abatacept 

  Brunner, Hermine; Tzaribachev, Nikolay; Louw, Ingrid; Penades, Inmaculada Calvo; Avila-Zapata, Francisco; Horneff, Gerd; Foeldvari, Ivan J.; Kingsbury, Daniel; Gastanaga, Maria Eliana Paz; Wouters, Carine; Breedt, Johannes; Wong, Robert; Askelson, Margarita; Zhuo, Joe; Martini, Alberto J.; Lovell, Daniel; Ruperto, Nicolino (Wiley, 2023-11)

  OBJECTIVE : To investigate the frequency and trajectories of individual patients with polyarticular-course juvenile idiopathic arthritis (JIA) achieving novel composite end points on abatacept. METHODS : Data from a ...
• Quantifying assays : inhibition of signalling pathways of cancer 

  Anguelov, Roumen; Manjunath, Gandhi; Phiri, Avulundiah Edwin; Nyakudya, Trevor Tapiwa; Bipath, Priyesh; Serem, June Cheptoo; Hlophe, Yvette Nkondo (Oxford University Press, 2023-09)

  Please read abstract in the article.
• Characterising coordination strategies during initial acceleration in sprinters ranging from highly trained to world class 

  Donaldson, Byron J.; Bezodis, Neil; Bayne, Helen (Routledge, 2024)

  Identifying coordination strategies used by sprinters and features that differentiate these strategies will aid in understanding different technical approaches to initial sprint acceleration. Moreover, multiple effective ...
• Do five screening tools identify the same number of runners who require pre-exercise medical clearance? SAFER XXXIV 

  Smith, Chanel; Sewry, Nicola; Nolte, Kim; Swanevelder, Sonja; Engelke, Nina; Van Kamp, Calvin; Jordaan, Esme; Schwellnus, Martin Peter (Taylor and Francis, 2024)

  OBJECTIVES : Currently, there are five international screening tools that are recommended to identify individuals who require pre-exercise medical clearance to reduce the risk of medical encounters during exercise. Therefore, ...
• A pilot study evaluating the ex vivo effects of varying factor VIII concentration on clot kinetics and architecture in patients with haemophilia A 

  Morris, Chanel; Potgieter, Johan C.; Bester, Janette (Sage, 2023)

  BACKGROUND : Haemophilia A (HA) is a bleeding disorder, due to a deficiency in factor VIII (FVIII). These patients are unable to produce a stable fibrin clot in the propagation phase of coagulation as they do not generate ...
• A high incidence of injury among male university student rugby players requires urgent injury prevention strategies 

  Van Zyl, Sanet; Bayne, Helen; Schwellnus, Martin Peter; Viljoen, Carel Thomas (Elsevier, 2024-01)

  OBJECTIVES : Determine the epidemiology and clinical characteristics of training and match injuries in university student rugby players over a two-season period. DESIGN : Prospective cohort. SETTING : Varsity Cup (VC) ...
• Exploring the ex vivo effects of Naja mossambica venom on the ultrastructure and viscoelastic properties of human blood 

  Chamboko, Tanyaradzwa Dellah; Love, Jenna; Strydom, Morne; Bester, Janette (Elsevier, 2024-01)

  BACKGROUND : Venomous snake bites have been listed as a neglected tropical disease by the World Health Organization. The Mozambique spitting cobra (Naja mossambica) is found in Sub-Saharan African countries, and its venom ...
• Considerations for enhanced mesenchymal stromal/stem cell myogenic commitment in vitro 

  Grobbelaar, Simone; Mercier, Anne Elisabeth; Van den Bout, Iman; Durandt, Chrisna; Pepper, Michael Sean (Wiley, 2024-01)

  The generation of tissue from stem cells is an alluring concept as it holds a number of potential applications in clinical therapeutics and regenerative medicine. Mesenchymal stromal/stem cells (MSCs) can be isolated from ...
• A review on the anti-hyperglycaemic potential of Catharanthus roseus and Portulacaria afra 

  De Vos, Brunhilde; Hayeshi, Rose K.; Pheiffer, Wihan; Nyakudya, T; Ndhlala, Ashwell R. (Elsevier, 2023-12)

  Diabetes mellitus is a prevalent non-communicable disease affecting individuals in developed and developing countries. However, low-income countries face significant challenges in managing diabetes due to socio-economic ...
• Adverse neurological effects after exposure to copper, manganese, and mercury mixtures in a Spraque-Dawley rat model : an ultrastructural investigation 

  Draper, Maxine; Bester, Megan; Van Rooy, Mia-Jeanne; Oberholzer, Hester Magdalena (Taylor and Francis, 2023)

  Exposure to environmental metal pollutants is linked to oxidative stress and the subsequent development of neurological disease. In this study, the effects of copper, manganese, and mercury, were evaluated at X100 the World ...
• Poor cardiorespiratory fitness in first year medical students at a South African University 

  Borresen, Jill; Celie, Bert; Laubscher, Ria; Bac, Martin; Wood, Paola; Camacho, Tanya Chantelle de Sousa; Nolte, Kim; Schwellnus, Marianne; Basu, Debashis; Schwellnus, Martin Peter (Taylor and Francis, 2024)

  The personal health behaviours, including physical activity, of healthcare professionals influence their counselling practices as they relate to non-communicable diseases (NCDs). However, despite the importance of producing ...
• Adverse effects of copper, manganese and mercury, alone and in mixtures on the aorta and heart of Spraque-Dawley rats 

  Janse van Rensburg, Maxine; Bester, Megan; Van Rooy, Mia-Jeanne; Oberholzer, Hester Magdalena (Sage, 2023-08)

  Cardiovascular diseases (CVD) are a common global cause of death and are therefore a major health concern. Inhaled or ingested environmental heavy metals contribute to the development of CVD. The aim of this study was to ...
• MicroRNA 155, factor XIII and type 2 diabetes mellitus and coronary heart disease 

  Phasha, Marry-Ann Ntanyane; Soma, Prashilla; Van Rooy, Mia-Jeanne; Phulukdaree, Alisa (Bentham Science Publishers, 2023-07)

  There is a rise in the number of individuals diagnosed with type 2 diabetes mellitus (T2DM) in South Africa. Cardiovascular disease is among the macrovascular complication of type 2 diabetes mellitus and accounts for the ...

View more